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StatisticalMethod
•
reset
1
vote
2
replies
261
views
Detecting genomic signatures of drug resistance breast cancer in transcriptomic data
TransOmicsData
signatureSearchData
StatisticalMethod
written 3 months ago by
olusolaxx
• 0
0
votes
1
reply
403
views
Can we compare 3 different experimental conditions with DESeq2?
DESeq2
StatisticalMethod
updated 8 months ago by
swbarnes2
★ 1.4k • written 8 months ago by
Esteban
• 0
0
votes
0
replies
329
views
Job:
Post-Doc: Development of a new method to study the distribution of the effect sizes of QTL
StatisticalMethod
Evolution
QuantitativeTrailLocus
Genetics
JobPosting
9 months ago
pierre.devillemereuil
• 0
0
votes
3
replies
952
views
Differences in differential analysis methods for RNA-Seq
DESeq2
StatisticalMethod
Proteomics
DifferentialExpression
RNASeq
updated 9 months ago by
ATpoint
★ 4.7k • written 9 months ago by
james.zhang20
• 0
2
votes
2
replies
2.5k
views
DESeq2 median of ratios normalization instead of VST or rlog for ordinations?
DESeq2
medianofratiostransformation
StatisticalMethod
Normalization
dispersion
13 months ago
Linton
• 0
1
vote
2
replies
943
views
How to perform longitudinal analysis using EdgeR
StatisticalMethod
FoldChange
edgeR
RNASeq
14 months ago
Sabiha
▴ 20
2
votes
2
replies
777
views
DESeq2: Comparison of single clinical sample to 4 normals using tumour cohort to infer dispersion of single sample
GeneExpression
DESeq2
RNASeqData
RNASeq
StatisticalMethod
15 months ago
Manthos
• 0
5
votes
2
replies
1.5k
views
DecideTest vs topTAGs in edgeR
RNAseq
StatisticalMethod
edgeR
updated 16 months ago by
Gordon Smyth
52k • written 16 months ago by
alvaroperona1
▴ 10
3
votes
2
replies
943
views
Does this RNAseq experiment require a repeated measures approach?
StatisticalMethod
RNASeqData
edgeR
DESeq2
updated 20 months ago by
Gordon Smyth
52k • written 20 months ago by
CDSPARKS
▴ 30
2
votes
3
replies
3.0k
views
deseq2 normalization and statistical method
normalization
deseq2
StatisticalMethod
updated 23 months ago by
ATpoint
★ 4.7k • written 23 months ago by
SH
▴ 10
2
votes
4
replies
1.0k
views
Model comparison in mean-dispersion trend in DESeq2
DESeq2
StatisticalMethod
2.0 years ago • updated 24 months ago
Loïc
• 0
0
votes
2
replies
1.1k
views
Using Multi-Dimensional Scaling (MDS) to produce a vector in order to account for patient bias when constructing DGE lists from RNA-seq datasets in R?
PrincipalComponent
StatisticalMethod
edgeR
MultidimensionalScaling
Normalization
2.0 years ago
rcreswell01
• 0
1
vote
3
replies
1.3k
views
Limma-voom with inverse probability weights (similar to sample weights)
limma
limma-voom
StatisticalMethod
updated 2.1 years ago by
Gordon Smyth
52k • written 2.1 years ago by
jay
▴ 10
0
votes
1
reply
703
views
DESeq2 paired multifactor test
DESeq2
StatisticalMethod
updated 2.2 years ago by
Michael Love
43k • written 2.3 years ago by
ijvechetti
▴ 10
0
votes
0
replies
836
views
Job:
Academic position in Non-clinical Biostatistics
JobPosting
StatisticalMethod
2.3 years ago
Laurent Gatto
1.6k
1
vote
2
replies
1.4k
views
Limma adj.p.value the same for many different p.values
limmaGUI
limma
adj.p.value
StatisticalMethod
2.4 years ago
walkerrh95
• 0
0
votes
0
replies
1.2k
views
Job:
Postdoctoral research scientist in computational biology/statistical genetics/functional genomics at Columbia University, USA
Alzheimer's
StatisticalMethod
Genetics
molecularQTL
FunctionalGenomics
2.4 years ago
gaow
• 0
0
votes
0
replies
726
views
Should I adjust p value for multi-levels (groups) and multi-variables?
StatisticalMethod
2.9 years ago
dong
▴ 10
2
votes
3
replies
5.1k
views
Differential gene expression and (adjusted) p-values
edgeR
StatisticalMethod
updated 2.8 years ago by
ruez.richard
• 0 • written 3.1 years ago by
tmms
• 0
6
votes
4
replies
1.3k
views
Limma prametrization
limm
MathematicalBiology
limmaGUI
StatisticalMethod
3.1 years ago
Giovanni
• 0
2
votes
7
replies
1.9k
views
EdgeR, tumor normal pair, no replicatie but multiple patients, to focus on individual patients not combined
edgeR
StatisticalMethod
3.4 years ago
Field -Ye
• 0
0
votes
2
replies
1.8k
views
To retrieve the transcript from gff file with the longest isoform
FunctionalAnnotation
StatisticalMethod
3.7 years ago
Aneesha
• 0
0
votes
1
reply
960
views
DESeq2 Design matrix
StatisticalMethod
DESeq2
updated 3.8 years ago by
Michael Love
43k • written 3.8 years ago by
Saif
• 0
6
votes
6
replies
2.1k
views
limma:arrayWeights() and the "prior.n" parameter for biological replicates? (PROTEOMICS)
Proteomics
limma
StatisticalMethod
updated 3.9 years ago by
Gordon Smyth
52k • written 4.0 years ago by
Steve
▴ 10
1
vote
3
replies
1.4k
views
How to assign random effect factor in DESeq2 desing?
StatisticalMethod
DESeq2
phyloseq
updated 4.0 years ago by
Michael Love
43k • written 4.0 years ago by
zardbid
• 0
0
votes
0
replies
1.5k
views
Why is `scale-free topology` estimated as -sign(slope) * (R^2) in WGCNA?
Network
StatisticalMethod
WGCNA
ExpressionData
4.1 years ago
jol.espinoz
▴ 40
0
votes
2
replies
898
views
p adjusted value not available
StatisticalMethod
DESeq2
updated 4.3 years ago by
Kevin Blighe
★ 4.0k • written 4.3 years ago by
marie
• 0
27 results • Page
1 of 1
Recent ...
Replies
Comment: DESeq2 It is correct to use interaction term for patient variability?
by
Bradley
• 0
I apologize, but I am still perplexed. I need to know the exact type of replication. Do we have many samples taken from the same tumor? You…
Comment: Differential variance analysis - can i use deseq2
by
Michael Love
43k
VST is valid for working with expression data on a variance stabilized scale, so yes. There are many papers that have used VST and then com…
Answer: Use of limma R package with targeted proteomics for DE analysis
by
Gordon Smyth
52k
It is usual to analyse log normalized values from Olink in limma. Just a straight log transformation should be sufficient. We find that `tr…
Comment: WGCNA
by
pammelala304
• 0
Thank you for your time and effort. I am so grateful! Play game [block blast](https://blockblastpuzzle.io) free.
Comment: Does anyone have the command to download all of the core_nt using blast_db_get()
by
Matthew Thornton
▴ 380
Ok. So I guess the core_nt is over 300Gb compressed. I can do it, but maybe it is better to just use ncbi-tools over the internet and just…
Votes
Comment: Different annotation packages (org.Mm.eg.db, EnsDb.Mmusculus.v79, BiomaRt) retu
Answer: normalizatino of dna methylation EPIC data
Answer: Differential expression of protein coding ENSGs (Ensembl IDs) | When to biomaRt?
Suggesting changing the "reply-to" field to the mailing list address.
Answer: UniProt.ws query for single UniRef90 ID takes several minutes
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leakerb
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Mark Dunning
★ 1.1k
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shepherl
4.1k
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Hugo Varet
▴ 80
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Fred Hutch (Recruiting)
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