Highlighting Significantly Associated Sites on Manhattan Plot using ggbio
0
0
Entering edit mode
graggsd • 0
@graggsd-11168
Last seen 7.9 years ago

Hi all,

I'm experiencing difficulty implementing the highlight.gr argument within the plotGrandlinear function of ggbio. I'm trying to highlight and label significant sites from an association study. I can produce a manhattan plot, but cannot seem to get my significant points highlighted and labeled. Sample code here:

highlight_gr <- gr[which(p.adjust(alt_fit$p.value[,3],
    method = "bonferroni") < 0.05),]
mcols(gr) <- -log10(alt_fit$p.value)

plotGrandLinear(gr,
    aes(y = dxMM),
    color = c("#7fc97f", "#fdc086"),
    cutoff = -log10(0.05 / length(gr)),
    cutoff.color = "black",
    hightlight.gr = highlight_gr,
    highlight.label = TRUE,
    highlight.col = "red") +
    theme(axis.text.x=element_text(angle=-90, hjust=0))
ggbio manhattan plot plotGrandLinear • 1.1k views
ADD COMMENT

Login before adding your answer.

Traffic: 948 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6