Retrieve the reactome ID of a protein
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@lluis-revilla-sancho
Last seen 4 days ago
European Union

If I want to retrieve the identifier of a protein in Reactome using the ENTREZ id I can't, both the PATHID and the REACTOMEID are the same. While if I understood correctly they should be different, REACTOMEID, would be the identifier for such protein and PATHID the identifier of the pathway where such protein is involved.

>library("reactome.db")

> select(reactome.db, keys = "3855", keytype = "ENTREZID", columns = "REACTOMEID")
'select()' returned 1:many mapping between keys and columns
  ENTREZID    REACTOMEID
1     3855 R-HSA-1266738
2     3855 R-HSA-6805567
3     3855 R-HSA-6809371
> select(reactome.db, keys = "3855", keytype = "ENTREZID", columns = "PATHID")
'select()' returned 1:many mapping between keys and columns
  ENTREZID        PATHID
1     3855 R-HSA-1266738
2     3855 R-HSA-6805567
3     3855 R-HSA-6809371
> sessionInfo()
R version 3.4.0 (2017-04-21)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: Ubuntu 16.04.2 LTS

Matrix products: default
BLAS: /usr/lib/libblas/libblas.so.3.6.0
LAPACK: /usr/lib/lapack/liblapack.so.3.6.0

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
 [3] LC_TIME=es_ES.UTF-8        LC_COLLATE=en_US.UTF-8    
 [5] LC_MONETARY=es_ES.UTF-8    LC_MESSAGES=en_US.UTF-8   
 [7] LC_PAPER=es_ES.UTF-8       LC_NAME=C                 
 [9] LC_ADDRESS=C               LC_TELEPHONE=C            
[11] LC_MEASUREMENT=es_ES.UTF-8 LC_IDENTIFICATION=C       

attached base packages:
[1] parallel  stats4    stats     graphics  grDevices utils     datasets
[8] methods   base     

other attached packages:
[1] reactome.db_1.59.1   AnnotationDbi_1.38.0 IRanges_2.10.0      
[4] S4Vectors_0.14.0     Biobase_2.36.2       BiocGenerics_0.22.0

loaded via a namespace (and not attached):
[1] compiler_3.4.0 DBI_0.6-1      memoise_1.1.0  Rcpp_0.12.10   RSQLite_1.1-2
[6] digest_0.6.12

reactome.db • 1.2k views
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Entering edit mode
alserg ▴ 280
@assaron
Last seen 4 months ago
St Louis, MO

I believe this information is not present in reactome.db package. You can try to check raw simplified reactome databse: http://reactome.org/pages/documentation/developer-guide/simplified-database/ There is a table with external identifiers. 

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