I get the following error when starting R: Error in .initContents() : couldn't find function "isGeneric" Error: .onLoad failed in 'loadNamespace' for 'Biobase' Fatal error: unable to restore saved data in .RData I just installed R version 2.1.0 and BioC release 1.6. on a gentoo linux machine. The .RData file was generated with the new version and distribution. When I cp .RData to a machine (gentoo linux) with R version 2.0.1, release 1.5, I have no difficulty starting R with the saved workspace image restored. The file .RData is about 30Mb. Thank you, Juerg Straubhaar UMass Med