Hello,

I am running the following code:

library(gage)
library(gageData)
kg.hsa <- kegg.gsets("hsa")

However, this returns the following error:

Error in curl::curl_fetch_memory(url, handle = handle) : 
  SSL peer certificate or SSH remote key was not OK [rest.kegg.jp]: SSL certificate problem: self-signed certificate

According to the error message, the problem is that the website has a self-signed certificate. I have googled some solutions for this type of error and they suggest the following:

1. Disable the SSL certificate Verification
2. Install the self-signed certificate and add to the system's trusted certificates
3. Update the version of R and the package

[Edit] I thought I had the latest version of R for Mac, but 4.4.3 version was released on 2/28/25. However, updating still did not solve my issue (see below).

Thank you,

Here is my session info:

sessionInfo( )
R version 4.3.3 (2024-02-29)
Platform: x86_64-apple-darwin20 (64-bit)
Running under: macOS Sonoma 14.7.4

Matrix products: default
BLAS:   /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib 
LAPACK: /Library/Frameworks/R.framework/Versions/4.3-x86_64/Resources/lib/libRlapack.dylib;  LAPACK version 3.11.0

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

time zone: America/New_York
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] gageData_2.40.0 gage_2.52.0    

loaded via a namespace (and not attached):
 [1] crayon_1.5.3            vctrs_0.6.5             httr_1.4.7              cli_3.6.4              
 [5] knitr_1.49              rlang_1.1.5             xfun_0.51               DBI_1.2.3              
 [9] png_0.1-8               GO.db_3.18.0            bit_4.5.0.1             S4Vectors_0.40.2       
[13] RCurl_1.98-1.16         Biostrings_2.70.3       htmltools_0.5.8.1       graph_1.80.0           
[17] stats4_4.3.3            KEGGREST_1.42.0         rmarkdown_2.29          Biobase_2.62.0         
[21] evaluate_1.0.3          bitops_1.0-9            fastmap_1.2.0           GenomeInfoDb_1.38.8    
[25] yaml_2.3.10             IRanges_2.36.0          memoise_2.0.1           compiler_4.3.3         
[29] RSQLite_2.3.9           blob_1.2.4              pkgconfig_2.0.3         XVector_0.42.0         
[33] rstudioapi_0.17.1       digest_0.6.37           R6_2.6.1                GenomeInfoDbData_1.2.11
[37] AnnotationDbi_1.64.1    tools_4.3.3             bit64_4.6.0-1           zlibbioc_1.48.2        
[41] BiocGenerics_0.48.1     cachem_1.1.0