I have a query regarding the analysis of GSEA Results. I have used GSEA to obtain the dysregulated KEGG pathways. Now, I want to rank the dysregulated KEGG pathways.

I have seen people ranking the dysregulated genes on the basis of log2Fold Change and p-value obtained from DESeq2. For genes, they use the decreasing order of log2FC * (-log10 p-value) to rank the genes.

So, is it logical to use NES * (- log10 Nominal p-value) for ranking the KEGG pathways?

Some posts on this topic:

https://www.google.com/search?q=site%3Asupport.bioconductor.org+GSEA+ranking+DESeq2