Question

Can I adjust weights by group in dreamlet(), like in voomByGroup(), with a random effect?

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jcollier • 0

@c7fb2467

Last seen 4 months ago

United States

Is it possible to adjust the weights used in dreamlet by group to account for distinct shapes of group-wise mean-variance trends (as is done by limma::voomByGroup ), but with a random effect in the formula?

dreamlet • 700 views

ADD COMMENT • link updated 5 months ago by gabriel.hoffman ▴ 160 • written 5 months ago by jcollier • 0

score 1 · Answer 1 · 2024-06-10

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Gordon Smyth 51k

@gordon-smyth

Last seen 21 minutes ago

WEHI, Melbourne, Australia

voomByGroup() itself can handle a random effect if you pass arguments block and correlation to it, same as for voom().

ADD COMMENT • link 5 months ago Gordon Smyth 51k

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I agree with Gordon. This is not currently supported by dream

ADD REPLY • link 5 months ago gabriel.hoffman ▴ 160