Hub genes selection in WGCNA
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suphamon.j ▴ 20
@a48b0d5d
Last seen 18 months ago
Japan

Hi, Is it important to consider the significance of the Pearson's correlation between gene significance value (GS) and connectivity (kWithin) when selecting hub gene candidates for further study in biological relation?

I have tested the correlation of module trait relationship. the result shown that 3 modules were significantly related to my trait of interest. Such as Yellow, Green, Tan

After that I have followed WGCNA tutorial, and I have found that among 3 modules above with significant module-trait relationship, there is only 1 module shown significance of the Pearson's correlation between gene significance value (GS) and connectivity (kWithin).

When selecting hub gene for further study in biological relation. Is it necessary to consider the significance of the Pearson's correlation between gene significance value (GS) and connectivity (kWithin) when selecting hub gene candidates to study.

Thank you very much in advance for your reply and comments. Best regards


# include your problematic code here with any corresponding output 
# please also include the results of running the following in an R session 

sessionInfo( )
wgcna WGCNA hubgene • 983 views
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ATpoint ★ 4.6k
@atpoint-13662
Last seen 10 hours ago
Germany

WGCNA is not a Bioconductor package. You won't find help here. biostars.org is an alternative, or Reddit.

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