Hi

I'm having issues getting IsoformSwitchAnalyseR working. When I put library(IsoformSwitchAnalyzeR)

I get the message below which I dont understand. I've restarted, updated everything, removed and reinstalled. Can anyone help ? Thank you.

Error: package or namespace load failed for 'IsoformSwitchAnalyzeR' in get(Info[i, 1], envir = env):
 lazy-load database '/Library/Frameworks/R.framework/Versions/4.3-arm64/Resources/library/edgeR/R/edgeR.rdb' is corrupt
In addition: Warning message:
In get(Info[i, 1], envir = env) : internal error -3 in R_decompress1



sessionInfo( )
R version 4.3.0 (2023-04-21)
Platform: aarch64-apple-darwin20 (64-bit)
Running under: macOS Monterey 12.4

Matrix products: default
BLAS:   /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib 
LAPACK: /Library/Frameworks/R.framework/Versions/4.3-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.11.0

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

time zone: Europe/London
tzcode source: internal

attached base packages:
[1] stats4    stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] pfamAnalyzeR_1.0.0          lubridate_1.9.2            
 [3] forcats_1.0.0               stringr_1.5.0              
 [5] dplyr_1.1.2                 purrr_1.0.1                
 [7] readr_2.1.4                 tidyr_1.3.0                
 [9] tibble_3.2.1                tidyverse_2.0.0            
[11] ggplot2_3.4.2               DEXSeq_1.46.0              
[13] RColorBrewer_1.1-3          AnnotationDbi_1.62.1       
[15] DESeq2_1.40.1               SummarizedExperiment_1.30.1
[17] GenomicRanges_1.52.0        GenomeInfoDb_1.36.0        
[19] IRanges_2.34.0              S4Vectors_0.38.1           
[21] MatrixGenerics_1.12.0       matrixStats_0.63.0         
[23] Biobase_2.60.0              BiocGenerics_0.46.0        
[25] BiocParallel_1.34.1         BiocManager_1.30.20        
[27] limma_3.56.1               

loaded via a namespace (and not attached):
  [1] splines_4.3.0                 later_1.3.1                  
  [3] BiocIO_1.10.0                 bitops_1.0-7                 
  [5] filelock_1.0.2                XML_3.99-0.14                
  [7] lifecycle_1.0.3               processx_3.8.1               
  [9] lattice_0.21-8                ensembldb_2.24.0             
 [11] magrittr_2.0.3                yaml_2.3.7                   
 [13] remotes_2.4.2                 httpuv_1.6.11                
 [15] sessioninfo_1.2.2             pkgbuild_1.4.0               
 [17] DBI_1.1.3                     pkgload_1.3.2                
 [19] zlibbioc_1.46.0               AnnotationFilter_1.24.0      
 [21] RCurl_1.98-1.12               rappdirs_0.3.3               
 [23] GenomeInfoDbData_1.2.10       genefilter_1.82.1            
 [25] annotate_1.78.0               codetools_0.2-19             
 [27] DelayedArray_0.26.2           xml2_1.3.4                   
 [29] tidyselect_1.2.0              futile.logger_1.4.3          
 [31] BiocFileCache_2.8.0           GenomicAlignments_1.36.0     
 [33] jsonlite_1.8.4                ellipsis_0.3.2               
 [35] survival_3.5-5                tools_4.3.0                  
 [37] progress_1.2.2                Rcpp_1.0.10                  
 [39] glue_1.6.2                    gridExtra_2.3                
 [41] usethis_2.1.6                 withr_2.5.0                  
 [43] formatR_1.14                  fastmap_1.1.1                
 [45] fansi_1.0.4                   callr_3.7.3                  
 [47] digest_0.6.31                 timechange_0.2.0             
 [49] R6_2.5.1                      mime_0.12                    
 [51] colorspace_2.1-0              biomaRt_2.56.0               
 [53] RSQLite_2.3.1                 utf8_1.2.3                   
 [55] generics_0.1.3                tximeta_1.18.0               
 [57] rtracklayer_1.60.0            prettyunits_1.1.1            
 [59] httr_1.4.6                    htmlwidgets_1.6.2            
 [61] S4Arrays_1.0.1                pkgconfig_2.0.3              
 [63] gtable_0.3.3                  blob_1.2.4                   
 [65] hwriter_1.3.2.1               XVector_0.40.0               
 [67] htmltools_0.5.5               profvis_0.3.8                
 [69] geneplotter_1.78.0            ProtGenerics_1.32.0          
 [71] scales_1.2.1                  png_0.1-8                    
 [73] lambda.r_1.2.4                rstudioapi_0.14              
 [75] tzdb_0.3.0                    reshape2_1.4.4               
 [77] rjson_0.2.21                  curl_5.0.0                   
 [79] cachem_1.0.8                  BiocVersion_3.17.1           
 [81] parallel_4.3.0                miniUI_0.1.1.1               
 [83] restfulr_0.0.15               pillar_1.9.0                 
 [85] grid_4.3.0                    vctrs_0.6.2                  
 [87] urlchecker_1.0.1              promises_1.2.0.1             
 [89] dbplyr_2.3.2                  xtable_1.8-4                 
 [91] tximport_1.28.0               VennDiagram_1.7.3            
 [93] GenomicFeatures_1.52.0        cli_3.6.1                    
 [95] locfit_1.5-9.7                compiler_4.3.0               
 [97] futile.options_1.0.1          Rsamtools_2.16.0             
 [99] rlang_1.1.1                   crayon_1.5.2                 
[101] ps_1.7.5                      plyr_1.8.8                   
[103] fs_1.6.2                      stringi_1.7.12               
[105] munsell_0.5.0                 Biostrings_2.68.0            
[107] lazyeval_0.2.2                devtools_2.4.5.9000          
[109] Matrix_1.5-4                  BSgenome_1.68.0              
[111] hms_1.1.3                     bit64_4.0.5                  
[113] KEGGREST_1.40.0               statmod_1.5.0                
[115] shiny_1.7.4                   interactiveDisplayBase_1.38.0
[117] AnnotationHub_3.8.0           memoise_2.0.1                
[119] bit_4.0.5