I think the error I'm seeing requires a back-end update for the new Gencode release (s?).

se <- tximeta(coldata) importing quantifications reading in files with read_tsv 1 2 3 4 5 6 7 8 9 10

tximeta needs a BiocFileCache directory to access and save TxDb objects. Do you wish to use the default directory: '/Users/jtobias/Library/Caches/org.R-project.R/R/BiocFileCache'? If not, a temporary directory that is specific to this R session will be used.

You can always change this directory later by running: setTximetaBFC() Or enter [0] to exit and set this directory manually now. This location can also be set by environmental variable TXIMETA_HUB_CACHE.

1: Yes (use default) 2: No (use temp)

Selection: 1 /Users/jtobias/Library/Caches/org.R-project.R/R/BiocFileCache does not exist, create directory? (yes/no): y couldn't find matching transcriptome, returning non-ranged SummarizedExperiment

This was released a few days ago? I haven't update the hashes for the package but will do so soon.