Question

Single-Cell Data Simulation from Bulk RNA-seq

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irvin.ng • 0

@bf8fc140

Last seen 2.2 years ago

Canada

Hello,

I'm just wondering if there are any packages or papers out there that simulate scRNAseq from bulk RNAseq. I've found a couple to that do the opposite (bulk RNAseq from scRNAseq) but can't seem to find what I was looking for.

Thanks!

SingleCell RNASeq RNASeqData scRNAseq • 1.7k views

ADD COMMENT • link updated 6 months ago by Arun • 0 • written 2.2 years ago by irvin.ng • 0

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Hi - I am wondering what you decided to do. I am currently in a similar condition where I need to create a toy scRNAseq data from bulk.

ADD REPLY • link 9 months ago wichaidi • 0

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Hey check these papers/tools

ADD REPLY • link 6 months ago Arun • 0

score 0 · Answer 1 · 2022-11-17

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Gordon Smyth 52k

@gordon-smyth

Last seen 4 hours ago

WEHI, Melbourne, Australia

I think most people would regard simulating scRNAseq from bulk RNAseq as impossible because bulk RNAseq does not provide information on how individual cells will behave.

ADD COMMENT • link 2.2 years ago Gordon Smyth 52k