This is where the installation failed. I tried installing DESeq2 on "R Studio Cloud" and it worked. I am assuming this is a mac issue.

If anyone knows what to do I would very much appreciate it! Very new to R so anything will help.

make: /opt/R/arm64/bin/gfortran: No such file or directory
make: *** [ttest.o] Error 1
ERROR: compilation failed for package ‘genefilter’
* removing ‘/Library/Frameworks/R.framework/Versions/4.2-arm64/Resources/library/genefilter’
Warning: installation of package ‘genefilter’ had non-zero exit statusERROR: dependency ‘genefilter’ is not available for package ‘DESeq2’
* removing ‘/Library/Frameworks/R.framework/Versions/4.2-arm64/Resources/library/DESeq2’
Warning: installation of package ‘DESeq2’ had non-zero exit status
The downloaded source packages are in
    ‘/private/var/folders/m8/yy1nt9zx0ml8cdfw89vh42lc0000gn/T/RtmpsB8dBM/downloaded_packages’

Please read the error message and google or use the search function. Asked many times before (gfortran, ARM Macs) cannot install edgeR on M1 Mac

From Bioc 3.16 on Bioconductor provides binaries for the new ARM Macbooks so an upgrade if Bioconductor might be easiest.