library("DESeq2")

Loading required package: S4Vectors Loading required package: stats4 Loading required package: BiocGenerics

Attaching package: ‘BiocGenerics’

The following objects are masked from ‘package:stats’:

IQR, mad, sd, var, xtabs

The following objects are masked from ‘package:base’:

anyDuplicated, append, as.data.frame, basename, cbind, colnames, dirname,
do.call, duplicated, eval, evalq, Filter, Find, get, grep, grepl, intersect,
is.unsorted, lapply, Map, mapply, match, mget, order, paste, pmax, pmax.int,
pmin, pmin.int, Position, rank, rbind, Reduce, rownames, sapply, setdiff, sort,
table, tapply, union, unique, unsplit, which.max, which.min

Error: package or namespace load failed for ‘S4Vectors’ in get(Info[i, 1], envir = env): cannot open file 'C:/Program Files/R/R-4.2.0/library/S4Vectors/R/S4Vectors.rdb': No such file or directory Error: package ‘S4Vectors’ could not be loaded

sessionInfo()

R version 4.2.0 (2022-04-22 ucrt) Platform: x86_64-w64-mingw32/x64 (64-bit) Running under: Windows 7 x64 (build 7601) Service Pack 1

Matrix products: default

locale: [1] LC_COLLATE=English_United States.1252 LC_CTYPE=English_United States.1252
[3] LC_MONETARY=English_United States.1252 LC_NUMERIC=C
[5] LC_TIME=English_United States.1252

attached base packages: [1] stats4 stats graphics grDevices utils datasets methods base

other attached packages: [1] BiocGenerics_0.42.0

loaded via a namespace (and not attached): [1] compiler_4.2.0 tools_4.2.

```

This could be a sign of a b0rked installation, but I'd start with trying to reinstall the S4Vectors package and seeing what new issues (if any) present themselves.

So, what happens when you do:

BiocManager::install("S4Vectors")