HiCDCPlus with NO replicates
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ta_awwad ▴ 10
@ta_awwad-11382
Last seen 5 months ago
Frankfurt am Main

Hi everyone, I have two HiC data from two different conditions. I would like to calculate the differential interaction between these two conditions using HiCDCplus package. Is it possible to run hicdiff without replicates? if yes, how? if no, is there any other way to do so from .hic files? Thanks much Best, TA

hicdcdiff HiCDCPlus • 905 views
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hicdcdiff relies on DESeq2, which doesn't allow comparison of two conditions without replicates as significances cannot be determined reliably. You can check https://www.biostars.org/p/398152/ for a comprehensive set of discussions and links relating to this matter.

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