runDrugTarget_Annot_Bioassay throws an error
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komal.rathi ▴ 120
@komalrathi-9163
Last seen 14 months ago
United States

Hi,

I am trying to get the following code working, this is taken from the manual: https://www.bioconductor.org/packages/devel/bioc/vignettes/drugTargetInteractions/inst/doc/drugTargetInteractions.html#7_Workflow_to_Run_Everything

The code works on their example genes i.e. CA7 and CFTR but does not work on several other genes including the example below:

library(drugTargetInteractions)
# if we use their example genes i.e. c("CA7", "CFTR"), this is going to work but does not work with many genes and example is below 
genes <- c("HOXC11", "HOXC12")
chembldb <- system.file("extdata", "chembl_sample.db", package="drugTargetInteractions")
resultsPath <- system.file("extdata", "results", package="drugTargetInteractions")
config <- genConfig(chemblDbPath=chembldb, resultsPath=resultsPath)
downloadUniChem(config=config)
cmpIdMapping(config=config)

# convert to ensembl gene id - gene symbol vector
idMap <- getSymEnsUp(EnsDb = "EnsDb.Hsapiens.v86", ids = genes, idtype = "GENE_NAME")
ens_gene_id <- idMap$ens_gene_id
queryBy <- list(molType="gene", idType = "ensembl_gene_id", ids = names(ens_gene_id))
res_list <- getParalogs(queryBy)

# runDrugTarget_Annot_Bioassay
up_col_id = "ID_up_sp"  
drug_target_list <- runDrugTarget_Annot_Bioassay(res_list = res_list, 
                                                 up_col_id = "ID_up_sp", 
                                                 ens_gene_id = ens_gene_id,
                                                 config = config)

Error:

Error in vapply(names(ensids), function(x) ens_gene_id[ensids[[x]]], character(1)) : 
  values must be length 1,
 but FUN(X[[1]]) result is length 2

sessionInfo( )

R version 4.1.1 (2021-08-10)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Catalina 10.15.7

Matrix products: default
BLAS:   /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.1/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats4    parallel  stats     graphics  grDevices utils     datasets  methods  
[9] base     

other attached packages:
 [1] EnsDb.Hsapiens.v86_2.99.0    ensembldb_2.16.4            
 [3] AnnotationFilter_1.16.0      GenomicFeatures_1.44.1      
 [5] AnnotationDbi_1.54.1         Biobase_2.52.0              
 [7] GenomicRanges_1.44.0         GenomeInfoDb_1.28.1         
 [9] IRanges_2.26.0               S4Vectors_0.30.0            
[11] BiocGenerics_0.38.0          drugTargetInteractions_1.0.0

loaded via a namespace (and not attached):
 [1] MatrixGenerics_1.4.2        httr_1.4.2                  UniProt.ws_2.32.0          
 [4] bit64_4.0.5                 assertthat_0.2.1            BiocFileCache_2.0.0        
 [7] blob_1.2.2                  GenomeInfoDbData_1.2.6      Rsamtools_2.8.0            
[10] yaml_2.2.1                  progress_1.2.2              pillar_1.6.2               
[13] RSQLite_2.2.8               lattice_0.20-44             glue_1.4.2                 
[16] digest_0.6.27               XVector_0.32.0              Matrix_1.3-4               
[19] XML_3.99-0.7                pkgconfig_2.0.3             biomaRt_2.48.3             
[22] zlibbioc_1.38.0             purrr_0.3.4                 BiocParallel_1.26.1        
[25] tibble_3.1.3                KEGGREST_1.32.0             generics_0.1.0             
[28] ellipsis_0.3.2              cachem_1.0.6                withr_2.4.2                
[31] SummarizedExperiment_1.22.0 lazyeval_0.2.2              magrittr_2.0.1             
[34] crayon_1.4.1                memoise_2.0.0               fansi_0.5.0                
[37] xml2_1.3.2                  tools_4.1.1                 prettyunits_1.1.1          
[40] hms_1.1.0                   BiocIO_1.2.0                lifecycle_1.0.0            
[43] matrixStats_0.60.0          stringr_1.4.0               DelayedArray_0.18.0        
[46] Biostrings_2.60.2           compiler_4.1.1              rlang_0.4.11               
[49] grid_4.1.1                  RCurl_1.98-1.4              rstudioapi_0.13            
[52] rjson_0.2.20                rappdirs_0.3.3              bitops_1.0-7               
[55] restfulr_0.0.13             DBI_1.1.1                   curl_4.3.2                 
[58] R6_2.5.1                    GenomicAlignments_1.28.0    dplyr_1.0.7                
[61] rtracklayer_1.52.1          fastmap_1.1.0               bit_4.0.4                  
[64] utf8_1.2.2                  filelock_1.0.2              ProtGenerics_1.24.0        
[67] stringi_1.7.3               Rcpp_1.0.7                  vctrs_0.3.8                
[70] png_0.1-7                   dbplyr_2.1.1                tidyselect_1.1.1
runDrugTarget_Annot_Bioassay drugTargetInteractions • 459 views
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