Hello there, I came across an error while installing pacakge 'DEseq2' using BiocManager::install("DEseq2").

Bioconductor version 3.12 (BiocManager 1.30.10), R 4.0.4 (2021-02-15)
Installing package(s) 'DESeq2'
cannot open URL 'https://bioconductor.org/packages/3.12/data/annotation/bin/macosx/contrib/4.0/PACKAGES.rds': HTTP status was '404 Not Found'
cannot open URL 'https://bioconductor.org/packages/3.12/data/annotation/bin/macosx/contrib/4.0/PACKAGES.gz': HTTP status was '404 Not Found'
cannot open URL 'https://bioconductor.org/packages/3.12/data/experiment/bin/macosx/contrib/4.0/PACKAGES.rds': HTTP status was '404 Not Found'
cannot open URL 'https://bioconductor.org/packages/3.12/data/experiment/bin/macosx/contrib/4.0/PACKAGES.gz': HTTP status was '404 Not Found'
cannot open URL 'https://bioconductor.org/packages/3.12/workflows/bin/macosx/contrib/4.0/PACKAGES.rds': HTTP status was '404 Not Found'
cannot open URL 'https://bioconductor.org/packages/3.12/workflows/bin/macosx/contrib/4.0/PACKAGES.gz': HTTP status was '404 Not Found'
trying URL 'https://bioconductor.org/packages/3.12/bioc/bin/macosx/contrib/4.0/DESeq2_1.30.1.tgz'

Anyone knows what was happening here, was there a probelm regarding internet or soemthing else?

Welcome for any advice and suggestions. Many thanks in advance.

Hi,

We're not able to reproduce this. Can you try this again and show us the full output of the BiocManager::install("DEseq2") command?

FWIW the fact that these URLs cannot be accessed is expected (and is normally silently ignored), and it should not affect the final outcome i.e. you should still see that DESeq2 gets downloaded and installed.

Thanks,

H.