I am running into an error my code did not used to encounter. The data I am using ran with this code successfully 4 months ago. Any ideas on how to fix or circumvent this error would be appreciated.

> dds <- DESeqDataSetFromMatrix(countData=mycounts, 
                              colData=metadata, 
                              design=~condition,
                              tidy=TRUE)
> dds <- DESeq(dds)
> res <- results(dds, tidy=TRUE)

Error in checkSlotAssignment(object, name, value) : 
  assignment of an object of class “DFrame” is not valid for slot ‘elementMetadata’ in an object of class “DESeqResults”; is(value, "DataTable_OR_NULL") is not TRUE

These types of errors are nearly always caused by invalid installations, check:

BiocManager::valid()