Hi all, we have been working for the last month or so on integrating the Affymetrix parsing SDK 2.0 into an R package. We began because we had a CDF file which would not parse with the existing libraries in Bioconductor (the problem turned out to be in the CDF file itself). In any case, we have spent a good amount of time on providing an interface to this package in R, specifically duplicating the interfaces which are currently available in Bioconductor to the CDF, CEL, CHP, BPMAP, and BAR files (where relevant). One of the nice things about the library is that binary formats are also accepted so the same interface can parse both text and binary transparently. Also, it should be much easier to absorb new library changes when Affymetrix releases new SDKs and file formats. The library still needs some work, but before I spend a *lot* more time on it I wanted to know 1.) if people thought this would be good thing to have and 2.) if someone was already working on integrating these libraries. We are hopeful that people will think this is a good idea - we cannot see any reason why this would not be a good addition to Bioconductor, and would very much like to finish the work with the blessing of the BioC community. Thanks, jim -- James Bullard bullard@berkeley.edu 760.267.0986