Hello,

I am using SomaticSignatures package to find signatures in my data. I wonder how i can compare my results with signatures listed by the Sanger Institute (Figure 2 in the paper below)?

Signatures of mutational processes in human cancer http://www.nature.com/nature/journal/v500/n7463/full/nature12477.html

Thanks in advance

Sara

A comparison to published signatures should be fairly easy if once you have decided on a suitable measure for comparing the identified signatures. If you go with your example of the Kullback-Leibler divergence or the cosine similarity, you can compare the matrix we get from samples(sigs) to the 21 signatures published first on this. They are included in the package and you can access them with data(signatures21).

See also SomaticSignatures: Compare my datas with validated mutational signatures which discussed this before.