SC3 with latent variable corrected counts
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Mark ▴ 10
@mark-11758
Last seen 7.8 years ago
Imperial College London

I was just wondering if it's valid to perform SC3 clustering on latent variable normalised counts obtained for example from RUVSeq's RUVg or similar methods?

 

Thanks a lot,

Mark

SC3 single cell • 1.5k views
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@vladimir-kiselev-9342
Last seen 5.6 years ago
Sanger Institute, Cambridge, UK

Hi Mark,

Thanks for your question!

Yes, it is valid. SC3 treats RUV normalised counts the same way as counts normalised by any type of the size factor normalisations.

Cheers,

Vladimir

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