genes variances
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@e-motakis-mathematics-558
Last seen 10.2 years ago
Dear all, Recently, I have been working on variance stabilization techniques for cDNA microarrays. I have been studying the papers: I. Rocke and Durbin, (2001), `A model for measurement error for gene expression arrays', J. Comput. Biol, 8, 557--569 and II. Durbin, Hardin, Hawkins, and Rocke, (2002), `A variance- stabilizing transformation for gene-expression microarray data', Bioinformatics, 18, S105-S110. Their variance stabilization seems to work well for most of the genes I replicate (and for my data). I wonder if someone is aware of other related papers to that subject (not only by those authors). Is there any other technique for variance stabilization available in the microarrays literature? Thank you in advance. Makis Motakis ---------------------- E Motakis, Mathematics E.Motakis@bristol.ac.uk
Microarray Microarray • 830 views
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rgentleman ★ 5.5k
@rgentleman-7725
Last seen 9.6 years ago
United States
Hmm, google will do most of that work for you, Wolfgang Huber has done a lot of work on this (see the package vsn, which contains code for carrying out such an analysis). On Apr 22, 2005, at 5:12 AM, E Motakis, Mathematics wrote: > Dear all, > > Recently, I have been working on variance stabilization techniques for > cDNA microarrays. I have been studying the papers: > > I. Rocke and Durbin, (2001), `A model for measurement error for gene > expression arrays', J. Comput. Biol, 8, 557--569 and > > II. Durbin, Hardin, Hawkins, and Rocke, (2002), `A > variance-stabilizing transformation for gene-expression microarray > data', Bioinformatics, 18, S105-S110. > > Their variance stabilization seems to work well for most of the genes > I replicate (and for my data). I wonder if someone is aware of other > related papers to that subject (not only by those authors). Is there > any other technique for variance stabilization available in the > microarrays literature? > > Thank you in advance. > > Makis Motakis > > ---------------------- > E Motakis, Mathematics > E.Motakis@bristol.ac.uk > > _______________________________________________ > Bioconductor mailing list > Bioconductor@stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > > +--------------------------------------------------------------------- -- ----------------+ | Robert Gentleman phone: (206) 667-7700 | | Head, Program in Computational Biology fax: (206) 667-1319 | | Division of Public Health Sciences office: M2-B865 | | Fred Hutchinson Cancer Research Center | | email: rgentlem@fhcrc.org | +--------------------------------------------------------------------- -- ----------------+
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There is an interesting paper by Churchill (probably at his website at jax.org). At 10:44 AM 4/22/2005, Robert Gentleman wrote: >Hmm, google will do most of that work for you, Wolfgang Huber has done >a lot of work on this (see the package vsn, which contains code for >carrying out such an analysis). > >On Apr 22, 2005, at 5:12 AM, E Motakis, Mathematics wrote: > >>Dear all, >> >>Recently, I have been working on variance stabilization techniques for >>cDNA microarrays. I have been studying the papers: >> >>I. Rocke and Durbin, (2001), `A model for measurement error for gene >>expression arrays', J. Comput. Biol, 8, 557--569 and >> >>II. Durbin, Hardin, Hawkins, and Rocke, (2002), `A >>variance-stabilizing transformation for gene-expression microarray >>data', Bioinformatics, 18, S105-S110. >> >>Their variance stabilization seems to work well for most of the genes >>I replicate (and for my data). I wonder if someone is aware of other >>related papers to that subject (not only by those authors). Is there >>any other technique for variance stabilization available in the >>microarrays literature? >> >>Thank you in advance. >> >>Makis Motakis >> >>---------------------- >>E Motakis, Mathematics >>E.Motakis@bristol.ac.uk >> >>_______________________________________________ >>Bioconductor mailing list >>Bioconductor@stat.math.ethz.ch >>https://stat.ethz.ch/mailman/listinfo/bioconductor >> >+-------------------------------------------------------------------- --- >----------------+ >| Robert Gentleman phone: (206) 667-7700 > | >| Head, Program in Computational Biology fax: (206) 667-1319 | >| Division of Public Health Sciences office: M2-B865 > | >| Fred Hutchinson Cancer Research Center > | >| email: rgentlem@fhcrc.org > | >+-------------------------------------------------------------------- --- >----------------+ > >_______________________________________________ >Bioconductor mailing list >Bioconductor@stat.math.ethz.ch >https://stat.ethz.ch/mailman/listinfo/bioconductor Naomi S. Altman 814-865-3791 (voice) Associate Professor Bioinformatics Consulting Center Dept. of Statistics 814-863-7114 (fax) Penn State University 814-865-1348 (Statistics) University Park, PA 16802-2111
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