limma multi level experiment

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zzjerryzhang ▴ 10

@zzjerryzhang-11066

Last seen 8.8 years ago

Hello,

I have multi level experiment limma design. I want to ask after I create fit object by fit <- lmFit(v,design,block=targets$Subject,correlation=corfit$consensus), can I split fit by block to several small fit object to calculate coefficient within each block like original big fit object?

thanks

limma • 794 views

ADD COMMENT • link updated 8.8 years ago by Ryan C. Thompson ★ 7.9k • written 8.8 years ago by zzjerryzhang ▴ 10

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correction: it is not fit, it is v <- voom(dge,design,plot=TRUE), v has block, I split v to small v by block , then do the limma analysis to estimate coefficient within block, is it OK?

ADD REPLY • link 8.8 years ago zzjerryzhang ▴ 10

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Provide more details about your experimental design, it's impossible to figure it out from your description.
If you want to add more information, edit your question rather than posting a new answer.

ADD REPLY • link 8.8 years ago Aaron Lun ★ 28k

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