Dear Srini, Some meta-analysis references that might be of interest to you are: 1. "Combining multiple microarray studies and modeling interstudy variation". JK Choi et al.(2003) Bioinformatics. Vol.19 Suppl.1 pg i84-i90. 2. "Comparison and meta-analysis of microarray data: from the bench to the computer desk". Y Moreau et al.(2003) Trends in Genetics(19)10:570-577. 3. "Meta-analysis of microarrays: Interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer." D Rhodes et al.(2002) Cancer Research 62: 4427-4433. 4. Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies J.Wang et al (2004) Bioinformatics 20: 3166-3178 5. Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression D.R. Rhodes et al (2004) PNAS 101:9309-9314 6. The rmeta Package in R (Thomas Lumley) Regards, Marg Dr Margaret Gardiner-Garden Garvan Institute of Medical Research Sydney Australia -----Original Message----- From: bioconductor-bounces@stat.math.ethz.ch [mailto:bioconductor-bounces@stat.math.ethz.ch]On Behalf Of Rafael Irizarry Sent: Monday, February 28, 2005 5:54 AM To: Srinivas Iyyer Cc: bioconductor@stat.math.ethz.ch Subject: Re: [BioC] Comparision of expression values from 4 different studies what i did to combine data from 3 platofroms from 10 different labs is described here: http://www.bepress.com/jhubiostat/paper71/ -r On Feb 27, 2005, at 1:44 PM, Srinivas Iyyer wrote: > Dear group, I have 4 microarray studies. I am > interested in comparing the expression (expression > values) of my genes across these studies. > > I want to take expession value of gene A from first > study and and take expression values from other > studies, and compare them. Is this process > statistically allowed. or do i have to do some > treatments for all 4 studes, to bring to a some level > so that the expression values can be comparable. Is > meta-analysis is the way to go? please suggest.. > thank you very much > srini > > _______________________________________________ > Bioconductor mailing list > Bioconductor@stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor _______________________________________________ Bioconductor mailing list Bioconductor@stat.math.ethz.ch https://stat.ethz.ch/mailman/listinfo/bioconductor