I’m interested in using RUVseq but am having trouble installing it through R studio. I am using OS X El Capitan, but have had similar problems on a Windows 8 machine. Do you have any suggestions? I Have updated Biocinstaller. Here is the error message I get, followed by sessionInfo. Thanks,

### RUVSeq error message

biocLite("RUVSeq")

BioC_mirror: http://bioconductor.org

Using Bioconductor version 2.14 (BiocInstaller 1.14.3), R version 3.2.2.

Installing package(s) 'RUVSeq'

Warning message:

package ‘RUVSeq’ is not available (for R version 3.2.2) 

### sessionInfo()

sessionInfo()
R version 3.2.2 (2015-08-14)
Platform: x86_64-apple-darwin13.4.0 (64-bit)
Running under: OS X 10.11.2 (El Capitan)

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] BiocInstaller_1.14.3

loaded via a namespace (and not attached):
[1] tools_3.2.2

Hi,

you have a quite old version of Bioconductor: 2.14, while the current one is 3.2. Please, follow these steps to upgrade to the latest version of Bioconductor (https://www.bioconductor.org/install/#update-bioconductor-packages):

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("BiocUpgrade")

Note that you may need to upgrade to the latest R (3.2.3).

Best,

davide