I have just downloaded the bioconductor packages using the bioclite R script and wanted to use the library Variant Annotation.

I typed library(VariantAnnotation)

and received the following error messages:

Error in loadNamespace(j <- i[[1L]], c(lib.loc, .libPaths()), versionCheck = vI[[j]]) : 
  there is no package called ‘RCurl’
Error: package or namespace load failed for ‘VariantAnnotation’

Please advise

Did you try biocLite("RCurl")?

A system dependency for RCurl is libcurl, so you'll need to have that installed. If you get another error please show the error and output of sessionInfo().

Valerie