Is there some way in Bioconductor to correct for 3' bias in Highly amplified RNA samples for Affymetrix chips. I know that Affy now has a 3' biased human chip, but I have human data that was done with another chip and cannot be re-done. I also have mouse data and I don't think there is a 3' biased mouse chip from Affy. I've heard of people doing such a correction (not necessarily using BioC or R), but I can't find any mention of it in the affy documentation or in the Bioconductor mailing list archives. Thanks. -Ben