Dear Mr Smyth, I am a regular user of the R Limma package and I have some difficulty reading data published by Capital Bio corp on GEO (GSE11260). These data are bicolor microarray data. With read.myimages, I would like to exact the colums "SpotMedian.635", "BkgMedian.635", "SpotMedian.532", "BkgMedian.532" and "Flag". I am able to to this with read.table, but read.myimages seams to be uncapable. Thus, I can't proceed background correction. Would you have any idea that could help me? Thank you in advance Best regard -- Romain Desert - PhD Student INSERM UMR 991 Hopital Pontchaillou rue Henri Le Guilloux 35033 RENNES CEDEX 9 FRANCE T?l : 33-(0)6 38 43 49 37 romain.desert at inserm.fr http://inserm-umr991.univ-rennes1.fr/