Hi Bioconductors, The KEGGREST package is now available in devel (Bioconductor 2.12). http://www.bioconductor.org/packages/devel/bioc/html/KEGGREST.html KEGGREST is intended to replace the KEGGSOAP package, which is now deprecated. KEGGSOAP does not work since KEGG shut down its SOAP server at the end of 2012. Information about the transition from SOAP to REST is here: http://www.genome.jp/kegg/soap/ KEGGREST is designed to closely follow the KEGG REST API which is documented here: http://www.kegg.jp/kegg/docs/keggapi.html The REST interface is simpler and in some ways more powerful than the old SOAP interface. However, there is some functionality in the SOAP API which KEGG did not port to the REST API. KEGGREST is in devel, which means it is still subject to change. We welcome feedback about this package. Thanks, Dan