Hi, I use KeggProfile in my pipeline analysis and it's efficient, but I have problem with one pathway_ID. Exemple ( copy and paste): require(KEGGprofile) download_KEGGfile(pathway_id="04110",specis='hsa') #In this case , not problem download_KEGGfile(pathway_id="00910",specis='hsa') #this pahway exits in KEGG, but the download is impossible #[1] "Downloading files: 1/1" #essai de l'URL 'http://www.genome.jp/kegg- bin/download?entry=hsa00910&format=kgml' #Content type 'text/plain' length unknown #URL ouverte #downloaded 1 bytes #essai de l'URL 'http://www.genome.jp/kegg/pathway/hsa/hsa00910.png' #Erreur dans download.file(paste("http://www.genome.jp/kegg/pathway/", specis,  : #  impossible d'ouvrir l'URL 'http://www.genome.jp/kegg/pathway/hsa/hsa00910.png' #De plus : Message d'avis : #In download.file(paste("http://www.genome.jp/kegg/pathway/", specis, : #  ouverture impossible : le statut HTTP était '404 Not Found' My solution :  omit this pathway in my analysis: ponctual, fast  but not very elegant and not professional !! If someone has a suggestion , comments or solution, let's go , Thanks Greg Montréal > sessionInfo() R version 2.15.0 (2012-03-30) Platform: x86_64-pc-mingw32/x64 (64-bit) locale: [1] LC_COLLATE=French_Canada.1252  LC_CTYPE=French_Canada.1252 [3] LC_MONETARY=French_Canada.1252 LC_NUMERIC=C [5] LC_TIME=French_Canada.1252 attached base packages: [1] stats     graphics  grDevices utils     datasets  methods   base other attached packages:  [1] KEGGprofile_1.0.0    KEGG.db_2.8.0        RSQLite_0.11.2  [4] DBI_0.2-5            AnnotationDbi_1.20.0 Biobase_2.18.0  [7] BiocGenerics_0.4.0   TeachingDemos_2.8    png_0.1-4 [10] XML_3.95-0.1 loaded via a namespace (and not attached): [1] IRanges_1.16.2  parallel_2.15.0 stats4_2.15.0 [[alternative HTML version deleted]]