Hi all. This is slightly off-topic but I was wondering if anyone here knows where I might obtain a complete DNA or protein sequence for both BRCA1 and BRCA2? I retrieved protein sequence data from NCBI but I need to obtain two copies of each gene, i.e., one normal and another damaged for comparison purposes. I am unsure as to whether the protein sequences I have obtained are "healthy" copies. Thanks, ~Caitlin [[alternative HTML version deleted]]

Hi Caitlin, If you have found the protein sequences at NCBI Protein, they are (unless otherwise specified) what you could call 'healthy'. I am not quire sure what you mean by damaged copies. You will have to investigate the litterature to see which BRCA1/2 mutations are found in breast cancer. To my knowledge, there are several mutations in the BRCA genes which have been associated with a higher onset of especially breast cancer. You can use both UniProt and OMIM to investigate this. Best, David 2012/12/3 Caitlin <bioprogrammer at="" gmail.com="">: > Hi all. > > This is slightly off-topic but I was wondering if anyone here knows where I > might obtain a complete DNA or protein sequence for both BRCA1 and BRCA2? I > retrieved protein sequence data from NCBI but I need to obtain two copies > of each gene, i.e., one normal and another damaged for comparison purposes. > I am unsure as to whether the protein sequences I have obtained are > "healthy" copies. > > Thanks, > > ~Caitlin > > [[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor at r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor