Hi, I am so not a R expert so I apologize for the newbie question... If I have a list of gene symbols, can I get, for each of them, all GEO profiles for that gene across all platforms (or a subset of), extract normalized gene expression for that gene and feed this to LIMMA or the like to observe differential expression and make a list of all Datasets where this gene is differentially expressed? Sorry if this seems stupid; I promised to document any solution in our wiki and share it with the world ;-) Best regards Sylvain ============================================================== Sylvain Foisy, Ph. D. Charg? de projet | Project Manager Bioinformatics Labo. de g?n?tique et m?decine g?nomique de l'inflammation Centre de recherche Institut de cardiologie de Montr?al 5000 B?langer Est Montr?al, Qc H1T 1C8 CANADA T: (514) 376-3330 x.2299 F: 514-593-2539 M: sylvain.foisy at inflammgen.org W: http://inflammgen.org ==============================================================