RESEARCH ASSOCIATE - BIOSTATISTICS/BIOINFORMATICS Department of Plant Sciences, University of Cambridge Salary: £27,319-£35,646 pa Limit of Tenure applies* Genome-wide mapping and biostatistical analysis of meiotic recombination Meiotic recombination generates novel combinations of genetic variation via reciprocal exchange between homologous chromosomes. To better understand this process we are generating genome-wide recombination frequency maps in the model plant Arabidopsis thaliana. This research has important implications for population genetics and food security. The Research Associate will analyse high-throughput sequencing genotype data (Illumina) to generate recombination frequency maps. They will then model recombination frequency in terms of genomic (transcription, natural variation, small RNAs) and epigenomic (cytosine methylation, histone methylation, histone variants) features using publicly available whole genome datasets. The Research Associate will work jointly within Dr Ian Henderson's experimental research group and the Departmental Bioinformatics Group led by Dr Krys Kelly. The bioinformatics group currently consists of 6 people developing statistical methodology and analysing genome-wide patterns of small RNAs and epigenetic information in association with Prof Sir David Baulcombe. Applicants should have a Ph.D and substantial experience of a statistical language (e.g. R, Matlab). Experience in statistics, statistical genetics, quantitative genetics or genomics would also be beneficial. For further particulars please visit the Department website at http://www.plantsci.cam.ac.uk/jobs/index.html or contact Dr Ian Henderson (email: irh25@cam.ac.uk) To apply, please send a covering letter, CV, a Chris/6 cover sheet (parts I and III only) - http://www.admin.cam.ac.uk/offices/hr/forms/chris6/ - and the names and contact details (including email addresses) of 3 referees to Ombretta Orsini, Head of Department's Secretary, Department of Plant Sciences, Downing Street, Cambridge, CB2 3EA or email: oo203@cam.ac.uk * Limit of tenure: The post is available for 2 years, in the first instance. Quote Reference: PD07707,Closing Date: 23 February 2011 [[alternative HTML version deleted]]