Hi, Budhayash Just like steve stated, you can find the description in vignette about how to build a geneInput for GeneAnswers. Basically, the essential input is a vector of genes (Current version only supports Entrez IDs). But if you have any values associated with these genes, like foldchange, p-value, etc, the input can be a matrix or dataframe. In this case, the 1st column is always for gene Entrez IDs. You can find a case by this: >library(GeneAnswers) >data(humanGeneInput) >head(humanGeneInput) GeneID foldChange pValue 374 374 17.553825 1.241073e-11 2289 2289 10.549139 5.513686e-14 10563 10563 10.688601 1.073456e-10 687 687 6.112663 1.351898e-09 80149 80149 4.939585 6.473841e-09 5033 5033 4.265287 1.341238e-06 row names can be null. Best Gilbert On 9/30/10 7:50 AM, Steve Lianoglou wrote: > Hi, > > On Thu, Sep 30, 2010 at 4:07 AM, Budhayash Gautam > <budhayashgautam at="" gmail.com=""> wrote: >> hello everyone >> >> please tell me that how can we give input or >> in what manner we can give input to geneanswer >> >> thanks in advance > > Did you read through the vignette for the package? > http://www.bioconductor.org/packages/2.6/bioc/vignettes/GeneAnswers/ inst/doc/geneAnswers.pdf > > -steve >