Hello all, I am using the affy library with Gene ST arrays. In previous Bioconductor releases, mas5 failed because the algorithm cannot handle mm-values that are set on NA. However, in the current release mas5 normalization is performed succesfully. So I wonder: how are the mm- values estimated? I cannot find information on this in the NEWS file nor somewhere else. And is there some information available on the reliability of the calculated MAS5-values and corresponding P/M/A calls? Regards, Dr. Philip de Groot Ph.D. Bioinformatics Researcher Wageningen University / TIFN Nutrigenomics Consortium Nutrition, Metabolism & Genomics Group Division of Human Nutrition PO Box 8129, 6700 EV Wageningen Visiting Address: Erfelijkheidsleer: De Valk, Building 304 Dreijenweg 2, 6703 HA Wageningen Room: 0052a T: +31-317-485786 F: +31-317-483342 E-mail: Philip.deGroot at wur.nl<mailto:philip.degroot at="" wur.nl=""> Internet: http://www.nutrigenomicsconsortium.nl<http: www.nutrigenomi="" csconsortium.nl=""/> http://humannutrition.wur.nl/ https://madmax.bioinformatics.nl/