Dear useRs, Is there a possibility in R to go from differentially expressed genes to transcription factor binding sites (TFBS) that are enriched in the regulatory regions of the DE genes (comparable to DiRE from Dcode)? Maybe biomaRt together with a search in TransFac (which is not yet possible from R) could give a solution... Doing so, I would like to know whether there are (one or more) transcription factors, driving the observed differential expression. Just to be clear, I am not looking for differentially expressed transcription factors. Thanks a lot in advance for your help! Best regards, An [[alternative HTML version deleted]]