GO.db query error?
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Tim Smith ★ 1.1k
@tim-smith-1532
Last seen 10.2 years ago
Hi, I was trying a simple lookup - essentially looking up the Terms for specific GO IDs (GO:0048663 & GO:0060579). I reporduce the code and error I get: > library("GO.db") > Term(GOTERM[["GO:0048663"]]) [1] "neuron fate commitment" > Term(GOTERM[["GO:0060579"]]) Error in function (classes, fdef, mtable) : unable to find an inherited method for function "Term", for signature "NULL" I checked in AmiGO and both the terms are listed. Am I doing something wrong? thanks! PS: My sessionInfo is: --------------------------------------- > sessionInfo() R version 2.9.1 (2009-06-26) i386-pc-mingw32 locale: LC_COLLATE=English_United States.1252;LC_CTYPE=English_United States.1252;LC_MONETARY=English_United States.1252;LC_NUMERIC=C;LC_TIME=English_United States.1252 attached base packages: [1] stats graphics grDevices utils datasets methods base other attached packages: [1] biomaRt_2.0.0 GO.db_2.2.11 GOstats_2.10.0 [4] graph_1.22.2 Category_2.10.1 org.Hs.eg.db_2.2.11 [7] RSQLite_0.7-1 DBI_0.2-4 AnnotationDbi_1.6.1 [10] Biobase_2.4.1 loaded via a namespace (and not attached): [1] annotate_1.22.0 genefilter_1.24.2 GSEABase_1.6.1 RBGL_1.20.0 [5] RCurl_0.98-1 splines_2.9.1 survival_2.35-4 tools_2.9.1 [9] XML_2.5-3 xtable_1..5-5 > [[alternative HTML version deleted]]
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Marc Carlson ★ 7.2k
@marc-carlson-2264
Last seen 8.3 years ago
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Hi Tim, I suspect that you are not doing anything wrong. GO changes frequently. And this term is simply not present in the GO package that is online right now. The GO.db package is a snapshot of GO that matches the GO to gene mappings from the other .db packages that were also made at the same time. So to update it, I actually have to update all of the packages so that everything will be in sync. And we actually do this at least twice a year (with each release of Bioconductor). Amigo is a web based platform and so that should usually be more current. Whether or not that is an improvement over what we do depends on whether you want to place more emphasis on reproducibility or accuracy. Marc Tim Smith wrote: > Hi, > > I was trying a simple lookup - essentially looking up the Terms for specific GO IDs (GO:0048663 & GO:0060579). I reporduce the code and error I get: > >> library("GO.db") >> Term(GOTERM[["GO:0048663"]]) >> > [1] "neuron fate commitment" > >> Term(GOTERM[["GO:0060579"]]) >> > Error in function (classes, fdef, mtable) : > unable to find an inherited method for function "Term", for signature "NULL" > I checked in AmiGO and both the terms are listed. Am I doing something wrong? > thanks! > PS: My sessionInfo is: > --------------------------------------- > > >> sessionInfo() >> > R version 2.9.1 (2009-06-26) > i386-pc-mingw32 > > locale: > LC_COLLATE=English_United States.1252;LC_CTYPE=English_United States.1252;LC_MONETARY=English_United States.1252;LC_NUMERIC=C;LC_TIME=English_United States.1252 > > attached base packages: > [1] stats graphics grDevices utils datasets methods base > > other attached packages: > [1] biomaRt_2.0.0 GO.db_2.2.11 GOstats_2.10.0 > [4] graph_1.22.2 Category_2.10.1 org.Hs.eg.db_2.2.11 > [7] RSQLite_0.7-1 DBI_0.2-4 AnnotationDbi_1.6.1 > [10] Biobase_2.4.1 > > loaded via a namespace (and not attached): > [1] annotate_1.22.0 genefilter_1.24.2 GSEABase_1.6.1 RBGL_1.20.0 > [5] RCurl_0.98-1 splines_2.9.1 survival_2.35-4 tools_2.9.1 > [9] XML_2.5-3 xtable_1..5-5 > > > > > [[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor at stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor > >
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Just to clarify, I did not mean to imply that we are not accurate. A better choice of words might be to say that we are slightly less current (updating twice a year instead of continuously). But that this is a deliberate decision which allows us to have annotations that are versioned, synchronized relative to each other, and time-stamped. In turn, this trade-off should aid in making research more reproducible. Marc Marc Carlson wrote: > Hi Tim, > > I suspect that you are not doing anything wrong. GO changes > frequently. And this term is simply not present in the GO package that > is online right now. The GO.db package is a snapshot of GO that matches > the GO to gene mappings from the other .db packages that were also made > at the same time. So to update it, I actually have to update all of the > packages so that everything will be in sync. And we actually do this at > least twice a year (with each release of Bioconductor). Amigo is a web > based platform and so that should usually be more current. Whether or > not that is an improvement over what we do depends on whether you want > to place more emphasis on reproducibility or accuracy. > > > Marc > > > > > > Tim Smith wrote: > >> Hi, >> >> I was trying a simple lookup - essentially looking up the Terms for specific GO IDs (GO:0048663 & GO:0060579). I reporduce the code and error I get: >> >> >>> library("GO.db") >>> Term(GOTERM[["GO:0048663"]]) >>> >>> >> [1] "neuron fate commitment" >> >> >>> Term(GOTERM[["GO:0060579"]]) >>> >>> >> Error in function (classes, fdef, mtable) : >> unable to find an inherited method for function "Term", for signature "NULL" >> I checked in AmiGO and both the terms are listed. Am I doing something wrong? >> thanks! >> PS: My sessionInfo is: >> --------------------------------------- >> >> >> >>> sessionInfo() >>> >>> >> R version 2.9.1 (2009-06-26) >> i386-pc-mingw32 >> >> locale: >> LC_COLLATE=English_United States.1252;LC_CTYPE=English_United States.1252;LC_MONETARY=English_United States.1252;LC_NUMERIC=C;LC_TIME=English_United States.1252 >> >> attached base packages: >> [1] stats graphics grDevices utils datasets methods base >> >> other attached packages: >> [1] biomaRt_2.0.0 GO.db_2.2.11 GOstats_2.10.0 >> [4] graph_1.22.2 Category_2.10.1 org.Hs.eg.db_2.2.11 >> [7] RSQLite_0.7-1 DBI_0.2-4 AnnotationDbi_1.6.1 >> [10] Biobase_2.4.1 >> >> loaded via a namespace (and not attached): >> [1] annotate_1.22.0 genefilter_1.24.2 GSEABase_1.6.1 RBGL_1.20.0 >> [5] RCurl_0.98-1 splines_2.9.1 survival_2.35-4 tools_2.9.1 >> [9] XML_2.5-3 xtable_1..5-5 >> >> >> >> >> [[alternative HTML version deleted]] >> >> _______________________________________________ >> Bioconductor mailing list >> Bioconductor at stat.math.ethz.ch >> https://stat.ethz.ch/mailman/listinfo/bioconductor >> Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor >> >> >> > > _______________________________________________ > Bioconductor mailing list > Bioconductor at stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor > >
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