Hi, I just upgraded R to 1.8.0 and reloaded bioconductor and now get the following error when trying to load the affy library: > library(affy) Error in bindingIsLocked(m2, where) : not an environment Error in bindingIsLocked(m2, where) : not an environment Error in getClass(Class, where = topenv(parent.frame())) : "MIAME" is not a defined class Error in library(affy) : .First.lib failed Any ideas? BillK

You are using the release version of Bioconductor. You need to get the devel version if you are going to be using R-1.8.0. Unfortunately, the devel win32 affy package is not compatible with R-1.8.0, so it has to be compiled from source. The source files fail build, so I cannot send you an actual package, but I will send you a zipped affy folder that you can stick into your ~/rw1080/library folder. Run getBioC("affy","devel") to upgrade, and make sure that Biobase is upgraded to 1.3.34 (the bindingIsLocked error comes from Biobase 1.3.22), then replace the affy folder with what I send you and you should be good to go. Good luck! Jim James W. MacDonald Affymetrix and cDNA Microarray Core University of Michigan Cancer Center 1500 E. Medical Center Drive 7410 CCGC Ann Arbor MI 48109 734-647-5623 >>> W.Kenworthy@murdoch.edu.au 10/16/03 06:51AM >>> Hi, I just upgraded R to 1.8.0 and reloaded bioconductor and now get the following error when trying to load the affy library: > library(affy) Error in bindingIsLocked(m2, where) : not an environment Error in bindingIsLocked(m2, where) : not an environment Error in getClass(Class, where = topenv(parent.frame())) : "MIAME" is not a defined class Error in library(affy) : .First.lib failed Any ideas? BillK _______________________________________________ Bioconductor mailing list Bioconductor@stat.math.ethz.ch https://www.stat.math.ethz.ch/mailman/listinfo/bioconductor