Hello,
I have two gene lists and I want to find out whether there are genes
in
list one that occur in well known networks (KEGG?) where genes in list
2
also appear.
For example,
List 1: RAS, SPINK1
List 2: ERBB2
Both RAS and ERBB2 occur in ERBB signalling pathway defined by KEGG.
SPINK1 does not appear in any common network (I think).
Has anyone got any ideas what the best way to do this is?
Many thanks
Dan
--
**************************************************************
Daniel Brewer, Ph.D.
Institute of Cancer Research
Molecular Carcinogenesis
MUCRC
15 Cotswold Road
Sutton, Surrey SM2 5NG
United Kingdom
Tel: +44 (0) 20 8722 4109
**************************************************************
The Institute of Cancer Research: Royal Cancer Hospital, a charitable
Company Limited by Guarantee, Registered in England under Company No.
534147 with its Registered Office at 123 Old Brompton Road, London SW7
3RP.
This e-mail message is confidential and for use by the
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Just to answer my own question. It seems that with a combination of
the
annotation libraries "org.Hs.eg" and "KEGG", and a bit of scripting
you
can do this sort of thing.
Dan
Daniel Brewer wrote:
> Hello,
>
> I have two gene lists and I want to find out whether there are genes
in
> list one that occur in well known networks (KEGG?) where genes in
list 2
> also appear.
>
> For example,
>
> List 1: RAS, SPINK1
> List 2: ERBB2
>
> Both RAS and ERBB2 occur in ERBB signalling pathway defined by KEGG.
> SPINK1 does not appear in any common network (I think).
>
> Has anyone got any ideas what the best way to do this is?
>
> Many thanks
>
> Dan
>
>
--
**************************************************************
Daniel Brewer, Ph.D.
Institute of Cancer Research
Molecular Carcinogenesis
Email: daniel.brewer at icr.ac.uk
**************************************************************
The Institute of Cancer Research: Royal Cancer Hospital, a charitable
Company Limited by Guarantee, Registered in England under Company No.
534147 with its Registered Office at 123 Old Brompton Road, London SW7
3RP.
This e-mail message is confidential and for use by the
a...{{dropped:2}}
The tools in the gseaBase package are also pretty helpful for these
kinds of problems.
Florian
On 06.04.2009, at 08:07, Daniel Brewer wrote:
> Just to answer my own question. It seems that with a combination of
> the
> annotation libraries "org.Hs.eg" and "KEGG", and a bit of scripting
> you
> can do this sort of thing.
>
> Dan
>
> Daniel Brewer wrote:
>> Hello,
>>
>> I have two gene lists and I want to find out whether there are
>> genes in
>> list one that occur in well known networks (KEGG?) where genes in
>> list 2
>> also appear.
>>
>> For example,
>>
>> List 1: RAS, SPINK1
>> List 2: ERBB2
>>
>> Both RAS and ERBB2 occur in ERBB signalling pathway defined by
KEGG.
>> SPINK1 does not appear in any common network (I think).
>>
>> Has anyone got any ideas what the best way to do this is?
>>
>> Many thanks
>>
>> Dan
>>
>>
>
> --
> **************************************************************
> Daniel Brewer, Ph.D.
>
> Institute of Cancer Research
> Molecular Carcinogenesis
> Email: daniel.brewer at icr.ac.uk
> **************************************************************
>
> The Institute of Cancer Research: Royal Cancer Hospital, a
> charitable Company Limited by Guarantee, Registered in England under
> Company No. 534147 with its Registered Office at 123 Old Brompton
> Road, London SW7 3RP.
>
> This e-mail message is confidential and for use by the
a...{{dropped:
> 2}}
>
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