Dear all, I am writing this E-mail to announce the new package Rtreemix available in Bioconductor. Rtreemix is an easy-to-use package that offers an environment for estimating the mutagenetic trees mixture models from cross-sectional data and using them for various predictions. It includes functions for fitting the trees mixture models, likelihood computations, model comparisons, waiting time estimations, stability analysis, etc. The mixture of mutagenetic trees is an evolutionary model that provides an interpretable probabilistic framework for modeling multiple paths of ordered accumulation of permanent genetic changes that can be used for describing many disease processes. Each path captures a possible route of disease development. These models are used to model HIV progression characterized by accumulation of resistance mutations in the viral genome under drug pressure and cancer progression by accumulation of chromosomal aberrations in tumor cells. The available vignettes and the help files of the package provide detailed information on how to use the functions available in Rtreemix. Best, Jasmina