Dear All, I'm comparing 2 different, but similar tissue types (2 different parts of the nervous system), to work out the difference in expression between the two. My question is this, when performing background adjustment and normalisation, should I split the tissue types and work on each one seperately, or should I normalise for all against all? The tissue type are quite similar and an MAplot / pairs plot of all the expression values at probe level (before any analysis) shows fairly similar distributions of intensities between the different tissues. Many thanks, Jim

If you are interested, please go to Yale job posting website at http://www.yale.edu/hronline/stars/application/external/index.html to apply this job. STARS Req ID: 3475BR Department: Biotechnology Services University Generic Title: Biostatistician Job Category: Managerial & Professional Type of Employment: Full Time Salary Range: $49,500 - $75,500 Work Week: Standard - 37.5 hrs (M-F, 8:30-5:00) Worksite Address: 300 George Street, New Haven, CT Position General Purpose Provide biostatistical assistance and training for facility users as well as biomedical researchers in general. Essential Duties 1. Provide well-defined microarray, protein profiling, SNP association and other statistical analysis services. 2. Assist in designing experiments, e.g. web publish recommended procedures and animal experimental protocols need to provide statistically valid data. 3. Assist in preparing grant applications (e.g. make available "drop in" biostatistics sections for grant applications) and for Methods sections of papers. 4. Develop web-based Power Point tutorials for commonly needed statistical procedures (i.e. step by step directions for analyzing microarray data). 5. Evaluate various statistical data. 6. Evaluate new software. 7. Train microarray users and other biomedical researchers for data analysis. 8. Perform other duties as necessary. Education and Experience 1. Master's Degree in Biostatistics, Statistics or relevant field and two years of experience; or equivalent combination of education and experience. Additional Education and Experience 1. Basic knowledge of molecular biology and genetics; experience collaborating and consulting in biomedical environment. Skills & Abilities 1. Strong programming ability and knowledge of data analytic strategies. 2. Excellent written and verbal communication skills. 3. Sufficient knowledge of computer programming.