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No you don't look like an idiot and you are not doing anything wrong. What you are seeing is quite common from the standard implementation. A previous thread discussing this issue https://stat.ethz.ch/pipermail/bioconductor/2006-June/013276.html Best, Ben On Tue, 2008-02-05 at 19:06 -0800, Siobhan A. Braybrook wrote: > Dear all, > > At the risk of looking like an idiot: > is rma background correction supposed to make log-intensity histograms bimodal? > I noticed this in my own data, then checked it using the Dilution set too > (see below). > This seems weird to me........am I doing something wrong? > > data(Dilution) > dil.rma<- bg.correct(Dilution, method="rma") > hist(Dilution[,1:2]) > hist(dil.rma[,1:2]) > > > Thanks! > Siobhan > > S. A. Braybrook > Graduate Student, Harada Lab > Section of Plant Biology > University of California, Davis > Davis, CA 95616 > Ph 530.752.6980 > > The time is always right, to do what is right. > - Martin Luther King, Jr. > [[alternative HTML version deleted]] > > _______________________________________________ > Bioconductor mailing list > Bioconductor at stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor