Hi Alex, Here are some references: WJ Gauderman (2002), "Sample size requirements for matched case-control studies of gene-environment interaction", Stat Med 21:35-50. WJ Gauderman (2002), "Sample size requirements for association studies of gene-gene interaction", American Journal of Epidemiology, 155:478-484. WJ Gauderman (2003), "Candidate gene association studies for a quantitative trait, using parent-offspring trios", Genetic Epidemiology, 25:327-338. I think it works for quantitative trait. See the option 'continuous' in design. Pingzhao At 06:14 AM 1/30/2008, alex lam \(RI\) wrote: >Hi PingZhao, > >Are there any papers describing Quanto? And does it work with >quantitative traits? > >Thanks, >Alex > >-------------------------------------------- >Alex C. Lam >Roslin Institute (Edinburgh) >Midlothian >EH25 9PS >United Kingdom >Tel: +44 131 5274471 > >Roslin Institute is a company limited by guarantee, registered in >Scotland (registered number SC157100) and a Scottish Charity (registered >number SC023592). Our registered office is at Roslin, Midlothian, EH25 >9PS. VAT registration number 847380013. > >The information contained in this e-mail (including any attachments) is >confidential and is intended for the use of the addressee only. The >opinions expressed within this e-mail (including any attachments) are >the opinions of the sender and do not necessarily constitute those of >Roslin Institute (Edinburgh) ("the Institute") unless specifically >stated by a sender who is duly authorised to do so on behalf of the >Institute > > > >-----Original Message----- >From: bioconductor-bounces at stat.math.ethz.ch >[mailto:bioconductor-bounces at stat.math.ethz.ch] On Behalf Of pingzhao Hu >Sent: 29 January 2008 18:58 >To: bioconductor at stat.math.ethz.ch >Subject: [BioC] sample size estimation in genome wide association >studies / packages > > > Hi Philippe, > try Quanto software > [1]http://hydra.usc.edu/GxE/ > pingzhao > ======================================== > Pingzhao Hu > Statistical Analysis Facility > The Centre for Applied Genomics (TCAG) > The Hospital for Sick Children Research Institute > MaRS Centre - East Tower > 101 College Street, Room 15-705 > Toronto, Ontario, M5G 1L7, Canada > Tel.: (416) 813-7654 x6016 > Email: phu at sickkids.ca > Web: [2]http://www.tcag.ca/statisticalAnalysis.html > > >References > > 1. http://hydra.usc.edu/GxE/ > 2. http://www.tcag.ca/statisticalAnalysis.html >_______________________________________________ >Bioconductor mailing list >Bioconductor at stat.math.ethz.ch >https://stat.ethz.ch/mailman/listinfo/bioconductor >Search the archives: >http://news.gmane.org/gmane.science.biology.informatics.conductor ======================================== Pingzhao Hu Statistical Analysis Facility The Centre for Applied Genomics (TCAG) The Hospital for Sick Children Research Institute MaRS Centre - East Tower 101 College Street, Room 15-705 Toronto, Ontario, M5G 1L7, Canada Tel.: (416) 813-7654 x6016 Email: phu at sickkids.ca Web: http://www.tcag.ca/statisticalAnalysis.html