How to implement Stouffer's method using weights
0
0
Entering edit mode
Scott Ochsner ▴ 300
@scott-ochsner-599
Last seen 10.3 years ago
Hello, I have found a number of published papers which have used Fisher's and Stouffer's methods for combining p-values in microarray meta analysis, however much of the discussion is naturally described as mathematical formulas. As I'm not a statistician I'm having trouble interpreting these formulas as R code. The closest I have gotten is for Stouffer's: > pnorm(sum(qnorm(x))/sqrt(length(x))), which I got from a discussion on the BioC list serve archives. I would like to implement these methods in my own meta analysis and need help with the code, especially with recommendations as to what type of experimental weights make sense and how to code them. As a first thought I was thinking that the number of biological replicates would be a useful weight to incorporate into the analysis. Any help with a practical example of how to implement Fisher's and Stouffer's would be greatly appreciated. Scott A. Ochsner, Ph.D. Molecular and Cellular Biology Baylor College of Medicine Houston, TX. 77030 phone: 713-798-6227
Microarray Microarray • 1.2k views
ADD COMMENT

Login before adding your answer.

Traffic: 801 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6