Dear group, Apologies for asking a very lame question. I have a question about Fisher exact and hyperGTest used for functional analysis. Fishers exact test uses Hypergeometric distribution. GOStats has hyperGTest function where by giving set of parameters it calculates probabiliy of whether a set of genes are over or underrepresented for a functional category in a bigger set of genes. What is difference between these two tests. Which is prefered. Please help me understand. thanks srini ________________________________________________________________ ____________________ Be a better pen pal.