Dear group, i have a expression data matrix ( after RMA) with samples belonging to one cancer type (all adeno-carcinoma samples from gut and no normal or other type) how can i get genes that show variability across all samples. is this a non-parametric estimation and should i be doing annova? please suggest thanks

Srinivas Iyyer wrote: > Dear group, > > i have a expression data matrix ( after RMA) with > samples belonging to one cancer type (all > adeno-carcinoma samples from gut and no normal or > other type) > > how can i get genes that show variability across all > samples. > > is this a non-parametric estimation and should i be > doing annova? > You might try filtering by CV (which is just standard deviation/mean) if you are using single-channel data or by standard deviation if you are using common reference 2-channel data. Sean