I recently got a duo Intel Mac OSX and loaded many Bioconductor packages that I had been using along with R 2.5.1. All of the packages load and work except for tcltk, tkWidgets, ruuid, graph and GOstats. I get the same error as posted previously about tcltk and tkWidgets (last on Sep 19, 2006): >library(tcltk) Loading Tcl/Tk interface ... Error in dyn.load(x, as.logical(local), as.logical(now)) : unable to load shared library '/Library/Frameworks/R.framework/Versions/2.5/Resources/library/tcltk/ libs/i386/tcltk.so': dlopen(/Library/Frameworks/R.framework/Versions/2.5/Resources/library/ tcltk/libs/i386/tcltk.so, 10): Library not loaded: /usr/X11R6/lib/libX11.6.dylib Referenced from: /Library/Frameworks/R.framework/Versions/2.5/Resources/library/tcltk/l ibs/i386/tcltk.so Reason: image not found Error : .onLoad failed in 'loadNamespace' for 'tcltk' Error: package/namespace load failed for 'tcltk' Actually, loading ruuid gives me a slightly different message > library(ruuid) Error in library(ruuid) : there is no package called 'ruuid' However, all of the packages I'm running into trouble with are indeed loaded and presumably in the correct place. Any advice? Thanks, Michael.