Hi, This method has been implemented in our java based software HDBSTAT. It is available at http://www.ssg.uab.edu/hdbstat/ . It is a mature, standalone desktop application for microarray data analysis that implements the mix-o-matic procedure. If there is enough interest we will consider releasing this method as part of an R package on a 12 month timeframe. Hope this helps. Tapan Mehta Statistician 1 Section on Statistical Genetics, Univ. of Alabama at Birmingham tapan at uab.edu ----- Original Message ---- From: Claus Mayer <claus@bioss.ac.uk> Cc: bioconductor <bioconductor at="" stat.math.ethz.ch=""> Sent: Thursday, April 19, 2007 11:22:20 AM Subject: [BioC] Fitting mixture of beta-distributions Dear all! I assume that some of you are aware of a paper by Allison et al from 2002 where they discuss fitting a mixture of beta-distributions (one of them being the uniform) to the distribution of p-values from a microarray experiment. Has this been implemented into Bioconductor somewhere or is one of you aware of other R libraries that could help with fitting mixture of betas? Thanks, Claus -- ********************************************************************** ************* Dr Claus-D. Mayer | http://www.bioss.ac.uk Biomathematics & Statistics Scotland | email: claus at bioss.ac.uk Rowett Research Institute | Telephone: +44 (0) 1224 716652 Aberdeen AB21 9SB, Scotland, UK. | Fax: +44 (0) 1224 715349 _______________________________________________ Bioconductor mailing list Bioconductor at stat.math.ethz.ch https://stat.ethz.ch/mailman/listinfo/bioconductor Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor