Hi, Sorry about the late reply and many thanks for the bug report. This was due to a silly bug in AnnBuilder. Please find the corrected package at http://bioconductor.org/packages/2.0/data/annotation/html/humanCHRLOC. html I have only updated the source package. It is built by using source data download in Aug, 2006, therefore it is consistent with all other annotation data packages. I will upload a more updated version by Mar 15. Both source and windows binary will be availabe at that time. If you are in a hurry, I can send you the source package offline today. thanks again nianhua