Hi, I have Affymetrix 10k SNP data for 17 members of a family with a special disease (8 affected - 9 unaffected) and want to perform some kind of linkage or association analysis. The problem is that data is only available for about half the members of this family. There is only one person where the data of both father and mother is available. Any suggestions on how to analyze this kind of data would be very much appreciated! Best regards, Theresa

On Monday 18 December 2006 12:27, Theresa Scharl wrote: > Hi, > > I have Affymetrix 10k SNP data for 17 members of a family with a special > disease (8 affected - 9 unaffected) and want to perform some kind of > linkage or association analysis. The problem is that data is only > available for about half the members of this family. There is only one > person where the data of both father and mother is available. > > Any suggestions on how to analyze this kind of data would be very much > appreciated! It has been a while since I worked in that field, but you have looked at genehunter and merlin? As for missing data, that is the norm for family-based studies; most software for linkage analysis use likelihood-based methods that can account for the missing data. Sean