Hi All, I have a question regarding resampling-based corrections (maxT or minP) that are part of multtest. I have searched past archives and found some info By Prof Dudoit on this thread https://stat.ethz.ch/pipermail/bioconductor/2003-July/001947.html But I still need a clarification. It appears that when the resampling null distribution of t statistics vary across tests, maxT or minP single-step procedures will not be equally sensitive to all tests and this can be overcome by step-down minp/maxT. Does this mean maxT step-down procedure will be identically sensitive to all tests? Or is it that step-down method offers higher sensitivity over single- step by adjusting the unequal distributions across the tests, but the sensitivity across tests would still vary though to a smaller extent . Thank you for your response in advance. Archana _________________________________________________________________ One and only Ash. Find out all about her. Only on MSN Search